Preimplantation genetic screening PGS can benefit any couple at risk from passing on
genetic\chromosomal abnormalities.

Promoting excellence and professionalism in the delivery of laboratory services through patient – focused,
cost – effective diagnostic services.

The GenaTi team of researchers and scientists continues to work tremendously hard in order to set up new research
priorities and strategic directions for the GenaTi that are crucial to strengthening Saudi Arabia's health care system.

GenaTi contributes to the prevention of genetic diseases in the Kingdom of Saudi Arabia by offering
pre-implantation genetic diagnosis and screening in its new IVF clinic

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Preimplantation genetic diagnosis (PGD) and preimplantation genetic screening (PGS) are genetic testing procedures for screening embryos. The procedures offer couples who are likely to pass on a genetic abnormality, the possibility to become biological parents with minimal risk. It involves checking the genes and/or chromosomes of embryos created through In Vitro Fertilization (IVF).

PGS evaluates embryos for chromosomal abnormalities to make sure that they have the right number of chromosomes, having no extra or missing chromosome. PGD screens single-gene defects that may cause genetic disorders such as Thalassemia, Sickle cell anemia, Thrombophilia.


IVF

PGD and PGS require one extra step; the IVF treatment. During the IVF process, eggs removed from the ovaries and fertilized with sperm in the laboratory. Once the eggs have been fertilized and embryonic development begins, the embryologist performs an embryo biopsy, and genetic specialists determine which embryos carry a genetic anomaly and which are normal.



Who are the recommended cases for PGD/PGS/IVF?

 Sickle cell anemia, Thalassemia and single- gene disorders with confirmed pathogenic mutation
 If the affected gene is known, a custom PGD protocol will be designed and implemented
 If the affected gene is unknown to the couple, whole-exome sequencing will be offered to them to maximize the chances of
     identifying the underlying mutation
 Recurrent Abortions/Miscarriages (Normal karyotype)
 Recurrent IVF failure (2/3 or more)
 Advance Maternal Age (>35/38)