Preimplantation genetic screening PGS can benefit any couple at risk from passing on
genetic\chromosomal abnormalities.

Promoting excellence and professionalism in the delivery of laboratory services through patient – focused,
cost – effective diagnostic services.

The GenaTi team of researchers and scientists continues to work tremendously hard in order to set up new research
priorities and strategic directions for the GenaTi that are crucial to strengthening Saudi Arabia's health care system.

GenaTi contributes to the prevention of genetic diseases in the Kingdom of Saudi Arabia by offering
pre-implantation genetic diagnosis and screening in its new IVF clinic

❮❮
❯❯

Overview:

After the completion of the Human Genome Project Read (HGP), most of genes’ sequences and locations are determined. However, the full roles of those genes remains largely unknown. Functional genomics is the study of genes, their resulting proteins, and their functions/roles played in the biological and molecular processes. Therefore, the aim of functional genomics studies is to understand the complex relationships between genotype and phenotype on a global (genome-wide) scale. Studies investigate a range of processes such as transcription, translation and epigenetic regulation to answer relevant biological questions. For example and given the currently available information, we can assess which genes are present/expressed, say in a mouse/chicken model, and how they are organized? The subsequent question is to know if any of these genes or regulatory mechanisms involved in predisposition, development of a disease, or sensitivity to specific treatments? Elucidation of this type of data in humans represents one of the most challenging tasks in today's translational research, owing to the complexity of the biological systems and the hard-to-quantify interactions with the external environment. The rewards of functional genomics research, however, may be equally amazing.

Given its importance in the post-genomic era, the GenaTi Functional Genomics & Teratogenicity Screening Research service (GFGTSRS) is an important core research facility dedicated to support any functional genomic-based project. The GFGTSRS encompasses several different experimental approaches aimed at discovering the biological function of certain genes and defining how sets of genes and their products can interact in health and disease.

More specifically, the GFGTSRS focuses on teratogenicity & embryo-toxicity screening, carcinogenicity screening and the prevention of congenital malformations which are anatomical or structural abnormalities. Human fetuses could be born with such defects due to induction of impaired genetic factors or because the mother was exposed to medicinal/environmental insults (including chemicals such as drugs, pesticides, petroleum, heavy metals, air pollutants, industrial wastes, contaminated water, viruses, stressors, and malnutrition) or it could be due to a combination of genetic factors, drugs and environmental side effects during embryonic development.

It is pivotal to guarantee the safety of potential drugs. Carcinogenic effect can be easily missed in clinical studies, as it can take years of dosing and a high number of treated patients to see if a drug/agent induces cancer. Potential carcinogens, however, can be identified very early in in vitro or in vivo simple assay to look at the potential of substances to cause carcinogenicity. Moreover, the genetic factors and medicinal/environmental insults affect gene regulatory network that govern our health and function. It is important to determine experimentally which gene regulatory pathway has been affected. The GenaTi GFGTSRS platform will offer a robust and efficient teratogenicity, embryo-toxicity and carcinogenicity screening assays to scientists from industrial, pharmaceutical and academic fields who are interested to assess potential side effects of teratogens, toxins, carcinogens, air and water contaminants, pesticides, and any other chemical or environmental hazards.

Scope of services:
  To list the types of the congenital malformations (Teratogenicity) a given teratogen may induce
  To assess the potential hazard and measure the embryotoxicity of a given agent
  To assess the potential carcinogenicity of a given drug/agent
  As there are different types of mechanisms for genetic damage by an agent, we aim to offer identifying and analyzing the affected genes or pathways, RNA and/or proteins

List of offered services:

  1. Customized Functional Genomics Research service: Using Gain- and Loss-of-function approach, the GenaTi GFGTSRS offers investigation of the expression, function and regulation of a given gene. Thanks to dedicated expertise and platforms, the GFGTSRS works collaboratively with the researcher(s) to use several approaches in order to tailor the functional genomic study/service based on the need of the customer to professionally execute the applicant’s specific request. Animal models and cell lines can be used for several protocols such as to list a few: embryo microinjections, embryo in vitro and in vivo electroporation.

  2. Teratogenicity and Embryotoxicity Screenings: The GenaTi GFGTSRS offers this screening to assess and measure the adverse effects of a given drug or potential teratogen or toxin using:

      Embryonic stem cells [called Embryonic Stem Cell Test (EST)].
      Robust in vivo simple (chick embryo) or complex (mouse) animal model systems.
  3. Carcinogenicity Screening: A given agent/drug can be tested for carcinogenicity either using:
      In vitro mammalian or human stem cells
      In vivo chick or mouse animal models using either microinjection or electroporation

Results from the above-mentioned assays can be taken for further molecular and genetic analysis based on the specific customer’s request or needs.

Available Platforms:

  Electroporator
  Microinjector
  Microcapillary Puller
  Hybridization ovens
  Embryo incubators
  In situ hybridization and immunofluorescence staining facilities